Sliding scale pricing for self-pay patients
One Day TMS
ONE-D is an accelerated, physician-supervised TMS option that delivers
20 iTBS sessions in as little as one day.

In
30
Seconds

ONE-D (Optimized Neuroplastogen-Enhanced Depression) treatment compresses a therapeutic course into one intensive treatment day -
20 iTBS sessions delivered under physician supervision.

It’s a time-efficient, emerging option, augmenting treatment response with the use of two medications: D-cycloserine and Vyvanse. It is offered as a self-pay program currently (Inspire’s all-in cost:
$3,000).
What Is ONE-D (Single-Day TMS)?
Traditional TMS requires daily visits over many weeks - a significant barrier for people with work, family, or travel constraints. ONE-D addresses that barrier by delivering an intensive therapeutic treatment course in a single, tightly supervised day, while keeping the same safety and personalization steps used in standard and other accelerated TMS protocols. Early clinical reports and pilot data show encouraging response and remission rates (>70% response and near 50% remission) when conducted under careful clinical conditions.


How ONE-D works
- iTBS format: ONE-D uses repeated blocks of intermittent Theta Burst Stimulation (iTBS). Each iTBS block is brief (as little as 3 minutes), but the full 20-session schedule builds a cumulative neuroplastic effect.
- High density, short intervals: Repeats many short sessions with short rest periods; the accumulated stimulation aims to produce a stronger, faster biological shift. 600 pulses of iTBS are delivered every 30 minutes in just one day.
- Medication augmentation: Neuroplastogens (D-cycloserine and Vyvanse) are added the morning of treatments to enhance neuroplasticity — always under careful psychiatric supervision and informed consent.
- Individualized mapping & monitoring: Motor-threshold mapping and personalized targeting based on updated scalp heuristics are used before the session so stimulation is safe and tailored to you.
How ONE-D
compares to other options
| Option | Sessions | Typical timing | Insurance |
|---|---|---|---|
| Standard TMS | 36+ | 8 weeks | Often covered |
| 5-day Accelerated TMS | 50 | 5 days (10/day) | Self-pay ($7000) |
| ONE-D | 20 | 1 Day | Self-pay ($3,000) |

Evidence & outcomes
Several pilot and case-series on highly accelerated, neuroplastogen-enhanced protocols report high early response/remission rates (for example, single-day/accelerated protocols with up to ~90% response and ~74% remission rates at 6–12 weeks). These are promising early results; large randomized trials and longer-term follow-up remain an area of active study.
Accelerated protocols such as 50 sessions in 5 days (SAINT-style) have likewise demonstrated strong outcomes in trials and real-world clinic experience; ONE-D builds on that paradigm by intensifying delivery.

What to Expect
Psych history, med list, seizure risk check. (10–15 min consult available.)
Initial Consult & Screening
Done before treatment to personalize settings.
Mapping & Motor-Threshold
ONE-D treatment day(s)
Repeated brief iTBS sessions with staff monitoring; breaks provided.
PHQ-9 tracking and follow-up visits; touch-ups or maintenance plans discussed based on response.
Immediate & Scheduled Follow Up
Why Choose One-D?
Strong Results with Less Time Commitment
20 iTBS sessions in 1–2 days - many patients notice improvement within 2-6 weeks following treatment.
Physician-Supervised & Personalized
Planned and overseen by a TMS psychiatrist.
Ideal for Travelers & Time-Pressed Patients
Complete a full, physician-led course in a single trip.


Pros & Cons of One Day TMS
Pros
- Limited time commitment - 20 iTBS sessions in 1–2 days.
- Time-efficient - finish a full course in one trip.
- Physician-supervised - mapped and overseen by a psychiatrist.
- Non-invasive - outpatient, no anesthesia.
Cons
- Insurance limits - self-pay for single-day formats.
- Higher intensity - denser days result in no time for monitoring response over time or adjusting protocols.
- Not for everyone - strict medical screening required.
Frequently Asked Questions
What is ONE-D (Single-Day TMS)?
ONE-D is an accelerated TMS option that delivers 20 iTBS sessions in as little as one day, intended as a time condensed therapeutic course.
How Does ONE-D Work?
ONE-D uses repeated brief iTBS trains with short breaks so the brain receives a concentrated neuroplastic “dose.” This is combined with medication augmentation to enhance cortical excitability/response to the stimulation.
Who is a good candidate for ONE-D?
Candidates are usually adults with treatment-resistant depression and people who need a very time-condensed option (conflict to daily treatments or lack of accessibility to a TMS clinic). Everyone must pass psychiatric screening and be cleared by a TMS-trained psychiatrist. Read more: Is TMS right for me?
Are there any side effects of ONE-D?
When delivered with proper screening, mapping, and psychiatric oversight, ONE-D has been delivered safely in clinical settings. Common short-term effects include scalp discomfort, headache, and temporary fatigue.
How soon will I feel better after ONE-D?
Responses vary - some people notice improvement within days; many see fuller benefit over several weeks. ONE-D aims to accelerate the biological response, but timelines differ by individual.
How much does ONE-D cost and will insurance cover it?
ONE-D is a self-pay accelerated option (Inspire’s all-in price is $3,000). Insurers currently do not cover single-day formats; some payers (e.g., Medicare/Cigna) allow two sessions/day to speed up a standard course of TMS, but not more than this. We recommend a benefits check to confirm your plan options and costs. Read more about TMS Costs
How should I prepare for a ONE-D visit? What should I bring?
Plan for a long clinic day - bring snacks, headphones, and comfortable clothes. Stay hydrated and prepare for a quick breaks - only 20-25 minutes. Our accelerated room provides a comfortable space for privacy and to relax in between sessions.
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Our shared inspiration is to alleviate mental illness and improve the mental wellbeing of the patients we treat. We respect all backgrounds and cultures and want to hear our patient’s stories to best guide care. During treatment, we reinforce positive wellness practices, help maximize lifestyle modifications, and integrate rTMS therapy into a patient’s overall mental and physical health treatment.
Samuel B. Clinch, M.D
Medical Director

Services & Resources

Us vs Them
What sets Inspire TMS apart from typical TMS providers
Inspire TMS Denver
Sliding Scale Pricing Available
5-day Accelerated TMS Protocol
10–15 min call with Doctor
Focused Exclusively on TMS
>80% Clinic Response Rate
Cost Estimator Tool
15,000+ Treatments Completed
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Fixed Pricing Only
Often Unavailable
Long Wait or Intake Staff Only
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Unpublished or National Data
No estimator or Guidance
Unknown Volume
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Making TMS Affordable For Everyone
We believe cost should never be a barrier to effective care. That’s why we offer:
Coverage with most major insurance providers
Easy access to third-party financing options
Free 10–15 minute consultation to get started
Why Choose Inspire TMS Denver
We combine clinical expertise with a personalized, patient-first approach. From board-certified care and flexible pricing to proven treatment outcomes, we’re here to help you find lasting relief - with support every step of the way.

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Board-Certified Psychiatrist
Over 10 Years of Clinical Experience

Fast-Track TMS Option
5-Day Protocol for Faster Relief

Proven Patient Outcomes
Success Rates Tracked In-Clinic

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No Obligation, 10–15 Minute Intro Call

Personalized Care Plans
Tailored TMS Treatment for Every Patient

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