What Is Intermittent Theta Burst Stimulation (iTBS)?

Sam Clinch • October 27, 2025

A Faster, Effective Option for TMS Therapy

Inspire TMS Denver is proud to offer Intermittent Theta Burst Stimulation (iTBS), a second-generation form of Transcranial Magnetic Stimulation (TMS) that delivers the same benefits of traditional TMS in a fraction of the time.

The Science Behind iTBS

TMS was originally developed in the 1980s to study brain function, and over the years, it has evolved into a powerful treatment for depression and other mental health conditions. iTBS builds on this foundation by mimicking the brain’s natural theta wave activity, which plays a key role in learning and neural connectivity.


Unlike standard TMS that uses a repetitive pulse, iTBS delivers short bursts of pulses, stimulating the brain in a more natural and efficient pattern. The result? Shorter sessions and potentially faster symptom relief.

What Does iTBS Actually Mean?

Let’s break down the term:


  • Intermittent: Stimulation happens in short bursts, followed by rest.


  • Theta: Refers to the brain wave frequency - 5 Hz or one pulse every 200 milliseconds.


  • Burst: Each burst includes three pulses delivered just 20 milliseconds apart.


This unique method promotes synaptic plasticity, helping to "reset" brain circuits that have become stuck in patterns of depression or anxiety.

iTBS vs Standard TMS: What’s the Difference?

Feature iTBS Standard TMS
FDA Cleared For Depression Depression
Session Time 3 minutes 19 minutes
Effectiveness 60%+ response rate 60%+ response rate
Approved Since 2018 Since 2008
Used in Accelerated TMS? Yes Yes

Key Benefits of Theta Burst Stimulation

  • Faster Treatments: Just 3 minutes per session.
  • Same Effectiveness: As standard TMS protocols.
  • Lower Maintenance Costs: Shorter sessions = less expense for out-of-pocket treatment.
  • Ideal for Accelerated TMS: Fits into compressed therapy schedules.
  • FDA Approved: Backed by years of research and clinical results.

Is iTBS Right for You?

At Inspire TMS Denver, we tailor every treatment plan to the individual. If you're interested in faster relief or a more cost-effective maintenance option, iTBS could be a great fit. During your free consultation, we’ll walk you through the options and help you decide the best path forward.


Want to learn more about Accelerated TMS or iTBS? Book Your Free Consultation

Every Question Answered

Want to know more about TMS? Check out this in-depth guide to TMS therapy with transparent and easy to understand explanations about TMS processes, protocols, and treated conditions.

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